Lacunar Bone Analysis¶
Parameters per Image¶
Parameter Name |
Output |
Unit |
Task Type |
|---|---|---|---|
Lacunar number |
Lc.N |
1 |
|
Lacunar density |
Lc.N/BV |
1/µm³ |
|
Lacunar total volume |
Lc.TV |
µm³ |
|
Lacunar porosity |
Lc.TV/BV |
1 |
|
Parameters per Lacuna¶
Parameter Name |
Output |
CSV Column Name |
Unit |
Task Type |
|---|---|---|---|---|
Lacunar volume |
Lc.V |
volume |
µm³ |
|
Lacunar surface area |
Lc.S |
surface_area |
µm² |
|
Lacunar surface area to volume ratio |
Lc.S/Lc.V |
area_volume_ratio |
1/µm |
|
Lacunar equancy |
Lc.Eq |
axis_ratio |
1 |
|
Orientation major axis radius |
Lc.Or1.Rd |
major_axis |
µm |
|
Orientation minor axis radius |
Lc.Or2.Rd |
minor_axis |
µm |
|
The measurements in Lucid.Bone.LacunarParameters above are based on voxel counting.
Parameters per Lacuna (ETH)¶
Additional parameters can be calculated using task types developed in collaboration with ETH Zurich. These measurements are based on surface meshes. See Case Study: Lacunae Analysis with ETH, Zurich for more details.
Parameter Name |
Symbol |
CSV Column Name |
Unit |
Task Type |
|---|---|---|---|---|
Lacunar volume |
Lc.V |
Volume (um^3) |
µm³ |
|
Lacunar surface area |
Lc.S |
Surface Area (um^2) |
µm² |
|
Lacunar surface area to volume ratio |
Lc.S/Lc.V |
Surface Area to Vol Ratio |
1/µm |
|
Lacunar stretch |
Lc.St |
Lc_St |
1 |
|
Lacunar oblateness |
Lc.Ob |
Lc_Ob |
1 |
|
Lacunar equancy |
Lc.Eq |
Minor to Major Axis Ratio |
1 |
|
Lacunar sphericity |
Lc.Sr |
akhter_sphr |
1 |
|
Lacunar angle |
Lc.θ |
Lc.theta |
Degree |
|
Orientation major axis radius |
Lc.Or1.Rd |
Major Axis (um) (radius) (from PCA on volume) |
µm |
|
Orientation minor axis radius |
Lc.Or2.Rd |
Minor Axis (um) (radius) (from PCA on volume) |
µm |
|
Orientation major axis x-coordinate |
Lc.Or1.X |
Lc.Or1_x |
1 |
|
Orientation major axis y-coordinate |
Lc.Or1.Y |
Lc.Or1_y |
1 |
|
Orientation major axis z-coordinate |
Lc.Or1.Z |
Lc.Or1_z |
1 |
|
Orientation minor axis x-coordinate |
Lc.Or2.X |
Lc.Or2_x |
1 |
|
Orientation minor axis y-coordinate |
Lc.Or2.Y |
Lc.Or2_y |
1 |
|
Orientation minor axis z-coordinate |
Lc.Or2.Z |
Lc.Or2_z |
1 |
|
Centroid x-coordinate |
Lc.Crd.X |
Centroid X |
µm |
|
Centroid y-coordinate |
Lc.Crd.Y |
Centroid Y |
µm |
|
Centroid z-coordinate |
Lc.Crd.Z |
Centroid Z |
µm |
|
Parameters per Image (ETH)¶
Parameter Name |
Output |
Unit |
Task Type |
|---|---|---|---|
Lacunar number |
Lc.N |
1 |
|
Lacunar volume |
Lc.V |
µm³ |
|
Lacunar surface area |
Lc.S |
µm² |
|
Lacunar surface area to volume ratio |
Lc.S/Lc.V |
1/µm |
|
Lacunar stretch |
Lc.St |
1 |
|
Lacunar oblateness |
Lc.Ob |
1 |
|
Lacunar equancy |
Lc.Eq |
1 |
|
Orientation major axis radius |
Lc.Or1.Rd |
µm |
|
Orientation minor axis radius |
Lc.Or2.Rd |
µm |
|
These are the mean values per image. Minimum, maximum, median and standard deviation are also available.
For larger studies ETH.Processing.LacunaeStatsReduce can aggregate these from multiple images.
References¶
Osteocyte Lacunar Biomarkers in Human Rare Bone Diseases Elliott Goff Diss. ETH Zurich, 2022. https://doi.org/10.3929/ethz-b-000541902
Large-scale osteocyte lacunar morphological analysis of transiliac bone in normal and osteoporotic premenopausal women. Elliott Goff, Adi Cohen, Elizabeth Shane, Robert R. Recker, Gisela Kuhn, Ralph Müller Bone, Volume 160, 2022, 116424. https://doi.org/10.1016/j.bone.2022.116424
Large-scale quantification of human osteocyte lacunar morphological biomarkers as assessed by ultra-high-resolution desktop micro-computed tomography. Elliott Goff, Federica Buccino, Chiara Bregoli, Jonathan P. McKinley, Basil Aeppli, Robert R. Recker, Elizabeth Shane, Adi Cohen, Gisela Kuhn, Ralph Müller Bone, Volume 152, 2021, 116094. https://doi.org/10.1016/j.bone.2021.116094
