Case Study: Femur Analysis with UKE, Hamburg

In collaboration with the Institute of Osteology and Biomechanics, UKE we used XamFlow and CLIP to analyse subchondral cysts in femoral heads.


“I’m really impressed!” – Felix Schmidt, Institute of Osteology and Biomechanics, UKE


  • Multiple samples of femoral head measured with SCANCO XtremeCT II

  • 17 GB per image

  • 6 images analysed initially


We used CLIP to implement four stages in a multi-object segmentation workflow:

  1. Bone mask and hull

  2. Cartilage mask and loss area

  3. Subchondral area mask

  4. Cysts

The CLIP curvelet filter was used to identify the subchondral area.



  • Rossinelli, D. (2019). CLIP

  • Chiba, K., Burghardt, A. J., Osaki, M., & Majumdar, S. (2014). Three-dimensional analysis of subchondral cysts in hip osteoarthritis: an ex vivo HR-pQCT study. Bone, 66, 140–145.